Dry eye disease also can be represented as keratoconjunctivitis sicca. It is a multi-factorial disorder of tears and ocular surface. The prevalence of this disease rises dramatically with the increasing age, hinders performance and leads to poor quality of life. Various contributory factors of dry eye are advanced age, female sex, abnormal corneal innervations, vitamin deficiency, hormonal imbalance, contact lens use, infection, environmental stress, ophthalmic surgery and some medications. The conventional approach in the treatment of dry eye is lubricating eye drops and tear substitutes. Frequent uses of these eye drops again causes drt eye. By considering all these limitations of modern science it is need of the hour to discover and establish a harmless management of Dry eye disease. In Ayurveda available drug or procedures like netra Kriyakalpa are well established holistic approach. So it is necessary to understand the pathophysiology and possible mechanism of drug pharmacotherapy.
Keywords– Tear, Tarpana, Shushkaksipaka, Dry eye disease, keratoconjunctivitis sicca.